An Important Measure to Combat Alzheimer Through Phytomedicine - A Way Forward Towards Nature Cure

Sneha V Thomas; Susmita Shukla*

There is an emerging interest in using music as a non-invasive non-pharmacological therapy for various mental disorders. The study of music and medicine is a rapidly growing field which had been largely focused on the use of music as a complementary therapy. Despite its evident universality and high social value, the ultimate biological role of music and its connection to brain disorders is poorly understood.


Impairment of Insulin Signalling Pathway Triggers a Series of Detrimental Effects in Alzheimer’s disease

Vidyasagar Naik Bukke*; Moola Archana

Alzheimer’s disease (AD) is the most common cause of dementia and cognition impairment that interferes with the daily life. AD has no cure, but treatments are available to reduce the symptoms. Accumulating evidence reveals a connecting link between the impaired insulin signalling and AD. Alterations in insulin signalling remains to be a crucial factor that alters the glucose metabolism impacting the bioenergetics of the cell leading to mitochondrial dysfunction, Aβ accumulation, tau hyperphosphorylation, deviations in glycosylation, impairment of glutamatergic neurotransmission...


Effect of Whole Body Vibration on Balance in Parkinson’s Disease-A Randomized Controlled Pilot Study

Andrea Dincher*; Georg Wydra

Background: Parkinson’s disease is the second most common neurodegenerative disease. The symptoms are treated with medication, physiotherapy, exercise and occupational therapy. The effect of Whole Body Vibration (WBV) as an alternative training method has already been investigated for several symptoms in Parkinson’s patients. Since the effect on the balance does not seem to be clear, the effectiveness of different application frequencies should be tested in this pilot study...


Current vs Emerging Natural Compounds-Based Treatments for Alzheimer’s Disease

Maria João Ramalho; Stéphanie Andrade; Meghna Dabur; Joana A. Loureiro*; Maria Carmo Pereira*

Alzheimer’s disease is a progressive and irreversible neurodegenerative disease that affects millions of people globally. Presently, AD is considered a serious health concern, a social and economic burden. There is still no medically accepted cure for AD. Current therapeutics that are marketed for AD treatment only attenuate the symptoms and have several side effects...


Neuroimaging and Neuropsychological differences between Early-Onset Alzheimer and Late-Onset Alzheimer

Francesco Sciancalepore*

Alzheimer’s Disease (AD) represents the most known and widespread neurodegenerative disorder. Every day neurologists diagnose a new AD case and current estimates suggest that over 46 millions of people live with this dementia worldwide [1]. The AD history started in 1901 when Alois Alzheimer observed a patient named Auguste Deter; a 51-year-old woman with strange behavioral symptoms and memory impairments. The woman showed symptoms as memory loss, confusion, language impairment and unpredictable, agitated, aggressive and paranoid behaviour...


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